Publications scientifiques 2009

1. Moreau A., Vicente R., Dubreuil L., Adjali O., Podevin G., Jacquet C., Deschamps JY., Klatzmann D., Cherel Y., Taylor N., Moullier P., Zimmermann VS., Efficient intrathymic gene transfer following in situ administration of a rAAV serotype 8 vector in mice and nonhuman primates. Mol. Ther. 2009 17(3):472-9

2. Stieger K, Schroeder J, Provost N, Mendes-Madeira A, Belbellaa B, Meur GL, Weber M, Deschamps JY, Lorenz B, Moullier P, Rolling F. Detection of Intact rAAV Particles up to 6 Years After Successful Gene Transfer in the Retina of Dogs and Primates. Mol Ther. 2009 17(3):516-23.

3. Ciron C., Cressant A., Roux F., Raoul S., Cherel Y., Hantraye P., Deglon N., Schwartz B., Barkats M., Heard JM, Tardieu M, Moullier P., Colle MA. AAV1-AAV2- and AAV5-mediated human alpha-iduronidase gene transfer in the brain of nonhuman primate : vector diffusion and bio distribution. Hum. Gene Ther. 2009. Jan 6 (Epub ahead of print)

4. Stieger K, Lheriteau E, Moullier P, Rolling F. –AAV-mediated gene therapy for retinal disorders in large animal models. ILAR J. 2009;50(2):206-24.

5. Lhériteau E, Libeau L, Stieger K, Deschamps JY, Mendes-Madeira A, Provost N, Lemoine F, Mellersh C, Ellinwood NM, Cherel Y, Moullier P, Rolling F. The RPGRIP1-deficient dog, a promising canine model for gene therapy. Mol Vis. 2009;15:349-61.

6. Van Vliet K, Mohiuddin Y, McClung S, Blouin V, Rolling F, Moullier P, Agbandje-McKenna M, Snyder RO. Adeno-associated virus capsid serotype identification: Analytical methods development and application. J Virol Methods. 2009 Aug;159(2):167-77. Epub 2009 Mar 26.

7. Moreau A, Hill M, Thébault P, Deschamps JY, Chiffoleau E, Chauveau C, Moullier P, Anegon I, Alliot Licht B, Cuturi MC. Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates. FASEB J. 2009 Sep;23(9):3070-7. Epub 2009 May 6.

8. Duque S, Joussemet B, Riviere C, Marais T, Dubreil L, Douar AM, Fyfe J, Moullier P, Colle MA, Barkats M. Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons. Mol Ther. 2009 Jul;17(7):1187-96. Epub 2009 Apr 14.

9. Ciron C, Cressant A, Roux F, Raoul S, Cherel Y, Hantraye P, Déglon N, Schwartz B, Barkats M, Heard JM, Tardieu M, Moullier P, Colle MA. Human alpha-iduronidase gene transfer mediated by adeno-associated virus types 1, 2, and 5 in the brain of nonhuman primates: vector diffusion and biodistribution. Hum Gene Ther. 2009 Apr;20(4):350-60.

10. Stieger K., Belbellaa B., Le Guiner C., Moullier P., Rolling F. In vivo gene regulation using tetracycline-regulatable system. Advanced Drug Delivery Reviews. 2009 2-61(7-8):527-41.

11. Leblond AL, Naud P, Forest V, Gourden C, Sagan C, Romefort B, Mathieu E, Delorme B, Collin C, Pages JC, Sensebe L, Pitard B, Lemarchand P. Developing cell therapy techniques for respiratory disease: Intratracheal delivery of genetically engineered stem cells in a murine model of airway injury. Hum Gene Ther. (2009) 20:1329-43.

12. McIlroy, D., Barteau, B., Cany, J., Richard, C. Gourden, P Cochon, S. and Pitard, B. DNA/amphphilic block copolymer nanospheres promote low dose DNA vaccination. Mol Ther. (2009) 17, 1473-1481

13. Vonarbourg, A., Passirani, C., Desigaux, L., Allard, E., Saulnier, P., Lambert, O., Benoit, J.P. and Pitard, B. The encapsulation of DNA molecules into biomimetic lipid nanocapsules. Biomaterials. (2009) 30:3197-204.

14. Chisholm, E.J., Vassaux, G., Martin-Duque, P., Chevre, R., Lambert, O., Pitard, B., Merron, A., Weeks, M. Burnet, J., Peerlinck, I., Dai, M.S., Alusi, G., Mather, S.J., Uchegbu, J.F., Schatzlein, A.G. and Patrick Baril. Cancer-specific Transgene expression by systemic injection of nanoparticles. Cancer Res. (2009) 69:2655-62.

15. Lamoureux F, Picarda G, Garrigue-Antar L, Baud’huin M, Trichet V, Vidal A, Miot-Noirault E, Pitard B, Heymann D, Rédini F. Glycosaminoglycans as potential regulators of osteoprotegerin therapeutic activity in osteosarcoma. Cancer Res. (2009) 69, 526-36.

16. David S, Pitard, B, Benoit, JP, Passirani, C. Non-viral nanosystems for systemic siRNA delivery. Pharmacol Res (2009) 62:100-14.

17. Morille M, Passirani C, Letrou-Bonneval E, Benoit JP, Pitard B. Galactosylated DNA lipid nanocapsules for efficient hepatocyte targeting. Int J Pharm. (2009) 379:293-300.

18. Biliczki P, Girmatsion Z, Brandes RP, Harenkamp S, Pitard B, Charpentier F, Hébert TE, Hohnloser SH, Baró I, Nattel S, Ehrlich JR. Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction. Heart Rhythm. ( 2009) 6:1792-801.