Publications scientifiques 2014

1. Cogne B, Snyder R, Lindenbaum P, Dupont JB, Redon R, Moullier P, Léger A. NGS Library preparation may generate artifactual intégration sites of AAV vectors. Nat Med 2014 June 5 ;20(6) :577-8.

2. Childers MK, Joubert R, Poulard K, Moal C, Grange RW, Doering JA, Lawlor MW, Rider BE, Jamet T, Danièle N, Martin S, Riviere C, Soker T, Hammer C, Van Wittenberghe L, Lockard M, Gua, X, Goddard M, Mitchell E, Barber J, Williams JK, Mack DL, Furth ME, Vignaud A, Masurier C, Mavilio F, Moullier P, Beggs AH, Buj-Bello A. Gene Therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. Sci Transl Med. 2014 Jan 22 ;6(220)

3. Bucher T, Dubreil L, Colle MA, Maquigneau M, Deniaud J, Ledevin M, Moullier P, Joussemet B. Intracisternal delivery of AAV9 results in oligodendrocyte and motor neuron transduction in the whole central nervous system of cats. Gene Ther.May ;21(5) :522-8

4. Montenegro-Miranda PS, Pichard V, Aubert D, Ten Bloemendaal L, Duijst S, de Waart DR, Ferry N, Bosma PJ. In the rat liver, adenoviral gene transfer efficiency is comparable to AAV. Gene Ther.2014 Feb ;21(2) :168-74.Epub2013 Nov 28.

5. Lhériteau E, Petit L, Weber M, Le Meur G, Deschamps JY, Libeau L, Mendes-Madeira A, Guihal C, François A, Guyon R, Provost N, Lemoine F, Papal S, El-Amraoui A, Colle MA, Moullier P, Rolling F. Successful gene therapy in the RPGRIP1-deficient dog : a large model of cone-rod dystrophy. Mol Ther.2014 Feb ;22(2) :265-77.Epub 2013 Oct4.

6. Klein D, Mendes-Madeira A, Schlegel P, Rolling F, Lorenz B, Haverkamp S, Stieger K. Immuno-Histochemical analysis of rod and cone reaction to RPE65 deficiency in the inferior and superior canine retina. PLoS One. 2014 Jan 21;9(1):e86304. doi: 10.1371/journal.pone.0086304. eCollection 2014 Jan 21

7. Le Guiner C, Stieger K, Toromanoff A, Guilbaud M, Mendes-Madeira A, Devaux M, Guigand L, Cherel Y, Moullier P, Rolling F, Adjali O. Transgene regulation using the tetracycline-inducible TetR-KRAB system after AAV-mediated gene transfer in rodents and nonhuman primates. PLoS One. 2014 Sep 23;9(9):e102538. doi: 10.1371/journal.pone.0102538. eCollection 2014.

8. Moreau A, Vandamme C, Segovia M, Marie Devaux2#, Guilbaud M, Tilly G, Jaulin N, Le Duff J, Cherel Y, Deschamps JY, Anegon I, Moullier P, Cuturi MC, Adjali O. Generation and in vivo evaluation of IL10-treated tolerogenic dendritic cells in a nonhuman primate model of AAV-based gene transfer. (submitted) 2014

9. Gernoux G, Guilbaud M, Dubreil L, Larcher T, Babarit C, Ledevin M, Jaulin N, Planel P, Moullier P, Adjali O, Early interaction of AAV8 with the host immune system following intramuscular delivery results in weak but detectable lymphocyte and dendritic cell transduction. Hum Gene Ther. 2014 Oct 21. [Epub ahead of print]

10. Ayuso E, Blouin V, Lock M, McGorray S, Leon X, Alvira MR, Auricchio A, Bucher S, Chtarto A, Clark KR, Darmon C, Doria M, Fountain W, Gao G, Gao K, Giacca M, Kleinschmidt J, Leuchs B, Melas C, Mizukami H, Müller M, Noordman Y, Bockstael O, Ozawa K, Pythoud C, Sumaroka M, Surosky R, Tenenbaum L, van der Linden I, Weins B, Wright JF, Zhang X, Zentilin L, Bosch F, Snyder RO, Moullier P. Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material. Hum Gene Ther. 2014 Nov;25(11):977-87.

11. Le Guiner C, Montus M, Servais L, Cherel Y, Francois V, Thibaud JL, Wary C, Matot B, Larcher T, Guigand L, Dutilleul M, Domenger C, Allais M, Beuvin M, Moraux A, Le Duff J, Devaux M, Jaulin N, Guilbaud M, Latournerie V, Veron P, Boutin S, Leborgne C, Desgue D, Deschamps JY, Moullec S, Fromes Y, Vulin A, Smith RH, Laroudie N, Barnay-Toutain F, Rivière C, Bucher S, Le TH, Delaunay N, Gasmi M, Kotin RM, Bonne G, Adjali O, Masurier C, Hogrel JY, Carlier P, Moullier P, Voit T. Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients. Mol Ther. 2014 Aug 4. doi: 10.1038/mt.2014.151. [Epub ahead of print]

12. Chuah MK, Petrus I, De Bleser P, Le Guiner C, Gernoux G, Adjali O, Nair N, Willems J, Evens H, Rincon MY, Matrai J, Di Matteo M, Samara-Kuko E, Yan B, Acosta-Sanchez A, Meliani A, Cherel G, Blouin V, Christophe O, Moullier P, Mingozzi F, VandenDriessche T. Liver-specific transcriptional modules identified by genome wide in silico analysis enable efficient gene therapy in mice and non-human primates. Mol Ther. 2014 Sep;22(9):1605-13. doi: 10.1038/mt.2014.114. Epub 2014 Jun 23.

13. Larcher T, Lafoux A, Tesson L, Remy S, Thepenier V, François V, Le Guiner C, Goubin H, Dutilleul M, Guigand L, Toumaniantz G, De Cian A, Boix C, Renaud JB, Cherel Y, Giovannangeli C, Condorcet JP, Anegon I, Huchet C. Characterization of dystrophin deficient rats : a new model for Duchenne muscular dystrophy. PLoS One.2014 Oct 13 ;9(10) :e110371. Doi : 10.1371/journal.pone.01100371. eCollection 2014.

14. Jeanson-Leh L, MLameth J, Krimi S, Buisset J, Amor F, Le Guiner C, Barthélémy I, Servais L, Blot S, Voit T, Israeli D. Serum Profiling Identifies Novel Muscle miRNA and Cardiomyopathy-Related miRNA Biomarkers in Golden Retriever Muscular Dystrophy Dogs and Duchenne Muscular Dystrophy Patients. Am J Pathol. 2014 Sep 3. S0002-9440(14)00439-8 Epub ahead of print.

15. Bakou S, Guigand L, Apreutese R, Apreutese A, Wyers M, Cherel Y. Myocytes changes and satellite cells proliferation following denervation of ald (anterior latissimus dorsi) and pld (posterior latissimus dorsi) muscles in two strains of turkey (meleagris gallopavo). J. Vet. Anat. 2014; 7:89-111

16. Hordeaux J, Dubreil L, Deniaud J, Iacobelli F, Moreau S, Ledevin M, Le Guiner C, Blouin V, Mendes-Madeira A, Rolling F, Cherel Y, Moullier P, Colle M-A. Efficient central nervous system aavrh10-mediated intrathecal gene transfer in adult and neonate rats. Gene Ther. 2014

17. Larcher T, Perrichon P, Vignet C, Ledevin M, Le Menach K, Lyphout L, Landi L, Clerandeau C, Le Bihanic F, Menard D, Burgeot T, Budzinski H, Akcha F, Cachot J, Cousin X. Chronic dietary exposure of zebrafish to pah mixtures results in carcinogenic but not genotoxic effects. Environmental Science and Pollution Research. 2014:Published online

18. Leveille P, Tarrade A, Dupont C, Larcher T, Dahirel M, Poumerol E, Cordier A, Picone O, Mandon-Pepin B, Jolivet G, Lévy R, Chavatte-Palmer P. Maternal high fat diet induces follicular atresia but does not affect fertility in adult rabbit offspring. Journal of Developmental Origins of Health and Disease. 2014; 5:88-97

19. Meikar O, Vagin VV, Chalmel Fdr, Sostar K, Lardenois A, Hammell M, Jin Y, Da Ros M, Wasik KA, Toppari J, Hannon GJ, Kotaja N. An atlas of chromatoid body components. RNA. 2014; 20:483-495

20. Mostyn A, Attig L, Larcher T, Dou S, Chavatte-Palmer P, Boukthir M, Gertler A, Djiane J, Symonds ME, Abdennebi-Najar L. Ucp1 is present in porcine adipose tissue and is responsive to postnatal leptin. Journal of Endocrinology. 2014; 223:M31-M38

21. Poo YS, Nakaya H, Gardner J, Larcher T, Schroder W, Le T, Major L, Suhrbier A. Ccr2 deficiency promotes exacerbated chronic erosive neutrophi-dominated chikungunya virus arthritis. Journal of Virology. 2014

22. Trapp S, Soubieux D, MARTY Hln, Esnault E, Hoffmann TW, Chandenier M, Lion A, Kut E, Quéré P, Larcher T, Ledevin M, Munier S, Naffakh N, Marc D. Shortening the unstructured, interdomain region of the non-structural protein ns1 of an avian h1n1 influenza virus increases its replication and pathogenicity in chickens. J Gen Virol. 2014

23. Yingyuad P, Mével M, Prata C, Kontogiorgis C, Thanou M, Miller A D. Enzyme-triggered PEGylated siRNA-nanoparticles for controlled release of siRNA. J. RNAi Gene Silencing. (2014) 10:490-499.

24. Lacourpaille L. Hug F., Guével A., Péréon Y., Magot A., Hogrel JY, Nordez A. Non-invasive assessment of muscle stiffness in patients with duchenne muscular dystrophy. Muscle Nerve. 2014 sept 3 10.1002/mus.24445 (Epub ahead of print).

25. Lacourpaille L. Hug F., Guével A., Péréon Y., Magot A., Hogrel JY, Nordez A. New insights on contraction efficiency in patients with Duchenne muscular dystrophy. J Appl Physiol (1985). 2014 Sep 15;117(6):658-62. doi: 10.1152/japplphysiol.00544.2014. Epub 2014 Aug 7.

26. Magot A, David A, Sternberg D, Péréon Y. Focal and abnormally persistent paralysis associated with congenital paramyotonia. BMJ Case Rep. 2014 Jun 17;2014. pii: bcr2014204430. doi: 10.1136/bcr-2014-204430.

27. Pignon C, Donnelly TM, Todeschini C, Deschamps JY, Roux FA Assessment of a blood préservation protocol for use in ferrets before transfusion. Vet Rec. 2014 Mar 15;174(11):277. doi: 10.1136/vr.102127. Epub 2014 Feb 11. PMID:24523302 [PubMed – indexed for MEDLINE]

28. Denard J, Jenny C, Blouin V, Moullier P, and Svinartchouk F. Different protein composition and functional properties of Adeno-Associated Virus 6 vector manufactured from the culture medium and cell lysates. Molecular Therapy – Methods & Clinical Development. July 2014.

29. Cubizolle A, Serratrice N, Skander N, Colle MA, Ibanes S, Gennetier A, Bayo-Puxan N, Mazouni K, Mennechet F, Joussemet B, Cherel Y, Lajat Y, Vite C, Bernex F, Kalatzis V, Haskins ME, Kremer EJ. Corrective GUSB transfer to the canine mucopolysaccharidosis VII brain. Mol Ther. 2014 Apr;22(4):762-73.

30. Eradame H, Guegan P, Pitard B, Rasolonjatovo B. An overview of the synthesis and gene transfer properties of triblock copolymers poly(2-methyl-2-oxazoline-b-tetrahydrofurane-b-2-methyl-2-oxazoline). Journal of Biomaterials and Nanobiotechnology. (2014) 5: 53-65.

31. Rolland-Debord C, Lair D, Roussey-Bihouée T, Hassoun D, Evrard J, Cheminant MA, Chesné J, Braza F, Mahay G, Portero V, Sagan C, Pitard B and Magnan A. Block copolymer/DNA vaccination induces an allergen-specific local response in a mouse model of house dust mite asthma. PLoS One. (2014) 31: e85976.

32. Yolaine Ollivier a, Armelle Magot a,b,*, Philippe Latour c, Julie Perrier a, Sandra Mercier a, Thierry Maisonobe d, Yann Péréon, Clinical and electrophysiological features in a French family presenting with seipinopathy. Neuromuscular Disorders, 2014, in press

33. Emmanuel Drouin, Yann Péréon. Duchenne or Meryon muscular dystrophy? Molecular Genetics and Metabolism, 2014 in press

34. Salama A, Fichou N, Malard M-A, Dubreil L, De Beaurepaire L, Viel A, Jegou D, Bosch S, Bach J-M. Microrna-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. Plos ONE. 2014