Eduard Ayuso, senior scientist and head of the innovative vectoroly team at Atlantic Gene Therapies has been nominated as the new “Investigator of the month” by the American Society of Gene and cell therpy”. http://www.asgct.org/new-investigator-of-the-month
During the 20 meeting of the World Muscle Society, which took place in Brighton (England) from September 30th to October 4th, our researcher Caroline Le Guiner has presented durin an oral session some encouraging results about the systemic treatment of Duchenne Muscular Dystrophy dogs using an AAV vector carrying a µDystrophin sequence. Presentation title : … [Read more]
Short-lived recombinant adeno-associated virus transgene expression in dystrophic muscle is associated with oxidative damage to transgene mRNA. Jean-Baptiste Dupont1–3, Benoit Tournaire1–3, Christophe Georger4, Béatrice Marolleau4, Laurence Jeanson-Leh4, Mireille Ledevin5, Pierre Lindenbaum2,3,6, Emilie Lecomte1–3, Benjamin Cogné1–3, Laurence Dubreil5, Thibaut Larcher5, Bernard Gjata4, Laetitia Van Wittenberghe4, Caroline Le Guiner1–4, Magalie Penaud-Budloo1–3, Richard O Snyder1,7,8, Philippe Moullier1–3,7 and … [Read more]
Human Gene Therapy journal cited the work of G. Gernoux et al. in a selection of “featured articles” from the latest issue (January 2015). The study is the result of a fruitful collaboration between two teams from Atlantic Gene Therapies: Immunology of AAV-based gene transfer and ONIRIS/INRA 703 (APEX). The authors showed that an intramuscular … [Read more]
November 2014 Vol. 25, No. 11 Cover : Purification of an adenoassociated virus vector from serotype 8 by cesium chloride gradient ultracentrifugation as described in the article Ayuso et al., on page 977. This picture shows the first CsCl gradient and how the vector is recovered with a syringe.