Vectors production center

The vector core of the Gene Therapy Laboratory of Nantes was created in 1997. The funding is essentially provided by the Association Française contre les Myopathies (AFM), the University Hospital (CHU) of Nantes, the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Region Pays de la Loire. The vector core has developed processes for production and characterization of viral vectors derived from adenovirus, lentivirus and adeno-associated virus (AAV). These vectors are intended to use for in vitro and in vivo gene transfer applications, for basic research or for evaluation of therapeutic strategies for cancer or inherited diseases treatment.

Today, the vectors production center (CPV), within the INSERM UMR1089 research unit (translational gene therapy for retinal and neuromuscular diseases), is composed of two groups working together :

  • A Development group, focusing on the development of new production tools, production and purification processes for clinical grade viral vectors, as well as quality controls for clinical applications. These developments are intended to be transferred to Atlantic Bio GMP (Saint-Herblain, France) or Genethon Bioprod (Evry, France) for production and characterization of clinical lots. The first achievement was the development of a production process for the AAV4-RPE65 vector for a phase 1/2 gene therapy clinical trial for Leber Congenital Amaurosis currently ongoing.
  • A vector core for production of research/pre-clinical grade viral vectors dedicated to academic and private teams.
    The CPV group and Atlantic Bio GMP are part, together with Genethon and GenoSafe, of the Preindustrial Gene Therapy consortium (PGT)logoCPV_PGT, funded since 2011 by the Agence Nationale de la Recherche (ANR) investment program for the future.

 

Team : Image3

Véronique Blouin, PhD

Eduard Ayuso, DVM, PhD

Mathieu Mével, PhD

Achille François, PhD

Christophe Darmon, Ingénieur

Sandy Douthe, Ingénieur

Nicole Brument, Ingénieur

Magalie Penaud-Budloo, Doctorante

Sylvie Saleun, Ingénieur Image2

Mélanie Martin, Ingénieur

Estelle Toublanc, Ingénieur

Cécile Robin, Chef de projet

Christophe Chevé, Technicien

Frédéric Broucque, Technicien

Aurélien Jacob, Ingénieur

Lucie Ménard, Technicienne

Emilie Lecomte, Technicienne

Aline Roblin, Technicienne

Maïlys Pennors, Technicienne LAV

Katell Harrouet, Technicienne

Karine Pavageau, Technicienne

Nathalie Caillé, Technicienne

Armelle Cassard, Technicienne

Linda Poiraudeau, Technicienne

Solène Vollant, Technicienne

Christine Audrain, Technicienne

Françoise Balter, Assistante plateforme

Mohammed Bouzelha, Ingénieur

Charlène Mendé, Technicienne logistique

Cynthia Ducoin, Technicienne logistique